IL-37 Gene Modification Enhances the Protective Effects of Mesenchymal Stromal Cells on Intestinal Ischemia Reperfusion Injury.

Dejun KongYonghao HuXiang LiDingding YuHongyue LiYiming ZhaoYafei QinWang JinBaoren ZhangBo WangHongda WangGuangming LiHao Wang

Published in: Stem cells international (2020)

The results suggest that IL-37 gene modification significantly enhances the protective effects of MSCs against intestinal IRI. In addition, NLRP3-related signaling pathways could be associated with IL-37-MSC-mediated protection.

Keyphrases

ischemia reperfusion injury
genome wide
copy number
signaling pathway
mesenchymal stem cells
genome wide identification
gene expression
drug induced