Altered levels of circulating CD8 + CXCR5 + PD-1 + T follicular cytotoxic cells in primary Sjögren's syndrome.

Xuwen ZhaiYanlin WangHui GuoZhaojun LiangMin FengYanyao WuYan QinXiangcong ZhaoChong GaoJing Luo

Published in: Clinical rheumatology (2022)

T cell subsets has therapeutic potential for pSS. Key Points • CD8+CXCR5+ T cells were expanded in the circulation of patients with pSS. • Reduced numbers CD8+Treg cells in pSS patients. • Increased CD8+CXCR5+PD-1+T cells in pSS patients with pulmonary involvement.

Keyphrases

induced apoptosis
end stage renal disease
cell cycle arrest
nk cells
chronic kidney disease
pulmonary hypertension
prognostic factors
peritoneal dialysis
cell death
oxidative stress
rheumatoid arthritis
signaling pathway
patient reported outcomes