Cerebrospinal fluid neurofilament light chain tracks cognitive impairment in multiple sclerosis.

Lorenzo GaetaniNicola SalvadoriViviana LisettiPaolo EusebiAndrea ManciniLucia GentiliAngela BorrelliEmilio PortaccioPaola SarchielliKaj BlennowHenrik ZetterbergLucilla ParnettiPaolo CalabresiMassimiliano Di Filippo

Published in: Journal of neurology (2019)

CSF NfL is higher in MS patients with CI and impaired IPS and verbal fluency. Large myelinated axons injury, causing neural disconnection, may be an important determinant of CI in MS and can be reliably measured through CSF NfL.

Keyphrases

cerebrospinal fluid
multiple sclerosis
cognitive impairment
mass spectrometry
white matter
ms ms
working memory