-----Gold nanostars obviate limitations to laser interstitial thermal therapy (LITT) for the treatment of intracranial tumors.

Ethan S Srinivasan Yang Liu Ren A Odion Pakawat Chongsathidkiet Lucas P Wachsmuth Aden P Haskell-Mendoza Ryan M Edwards Aidan J Canning Gavin Willoughby Joseph Hinton Stephen J Norton Christopher D Lascola Paolo F Maccarini Christopher L Mariani Tuan Vo-Dinh Peter E Fecci

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Our results provide evidence for use of GNS to improve the efficiency and potentially safety of LITT. The in vivo data support selective accumulation within intracranial tumors and amplification of laser ablation, and the GNS-infused phantom experiments demonstrate increased rates of heating, heat contouring to tumor borders, and decreased heating of surrounding regions representing normal structures.

Keyphrases

high speed
optic nerve
weight loss
electronic health record
high resolution
magnetic resonance
magnetic resonance imaging
heat stress
stem cells
nucleic acid
radiofrequency ablation
bone marrow
image quality
replacement therapy