Generation of cytotoxic aptamers specifically targeting fibroblast-like synoviocytes by CSCT-SELEX for treatment of rheumatoid arthritis.
Fang QiuDuoli XieHongzhen ChenZhuqian WangJie HuangChunhao CaoYiying LiangXu YangDong-Yi HeXuekun FuAiping LuChao LiangPublished in: Annals of the rheumatic diseases (2024)
CSCT-SELEX could be a promising strategy for developing cell-targeting and cytotoxic aptamers. SAPT8 aptamer selectively ablates RA-FLSs via modulating NCL-p53/Bcl-2 signalling, representing a potential alternative or complementary therapy for RA.
Keyphrases
- rheumatoid arthritis
- disease activity
- cancer therapy
- ankylosing spondylitis
- interstitial lung disease
- single cell
- gold nanoparticles
- cell therapy
- signaling pathway
- systemic lupus erythematosus
- sensitive detection
- combination therapy
- stem cells
- systemic sclerosis
- risk assessment
- bone marrow
- climate change
- replacement therapy
- label free
- quantum dots
- wound healing