Herbal Formula Modified Bu-Shen-Huo-Xue Decoction Attenuates Intervertebral Disc Degeneration via Regulating Inflammation and Oxidative Stress.

Jialiang Lin Jiong-Hui Gu Dongwei Fan Wei-Shi Li

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

This study reveals that MBSHXD has the characteristics of a "multi-component, multi-target, and multi-pathway" in the treatment of IDD by regulating inflammation and oxidative stress, and network pharmacology may provide a feasible method to verify the molecular mechanism of MBSHXD for IDD by combining with molecular docking.

Keyphrases

oxidative stress
molecular docking
dna damage
ischemia reperfusion injury
diabetic rats
induced apoptosis
molecular dynamics simulations
heat shock
signaling pathway
preterm infants
replacement therapy
heat stress