Blocking autophagy with chloroquine aggravates lipid accumulation and reduces intracellular energy synthesis in hepatocellular carcinoma cells, both contributing to its anti-proliferative effect.
Fengming XuHans-Michael TautenhahnOlaf DirschUta DahmenPublished in: Journal of cancer research and clinical oncology (2022)
Chloroquine impaired proliferation of HepG2 cells might be due to intracellular accumulation of lipids and inhibition of energy synthesis.