Endothelial Cell Insulin Signaling Regulates CXCR4 (C-X-C Motif Chemokine Receptor 4) and Limits Leukocyte Adhesion to Endothelium.

Thomas RathjenBritta KunkemoellerCarly T CederquistXuanchun WangSam M LockhartJames C PattiHanni WillenbrockGrith Skytte OlsenGro Klitgaard PovlsenHans Christian Beck Christina Lund KidholmQian LiKyoungmin ParkGeorge Liang King Christian Rask-Madsen

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

Endothelial cell insulin signaling limits leukocyte/endothelial cell interaction induced by SDF-1 through downregulation of CXCR4. Improving insulin signaling in endothelial cells or inhibiting endothelial CXCR4 may reduce immune cell recruitment to the vascular wall or tissue parenchyma in insulin resistance and thereby help prevent several vascular complications.

Keyphrases

endothelial cells
type diabetes
high glucose
insulin resistance
glycemic control
cell migration
vascular endothelial growth factor
signaling pathway
nitric oxide
adipose tissue
metabolic syndrome
cell proliferation
skeletal muscle
polycystic ovary syndrome
cystic fibrosis
weight loss
staphylococcus aureus