Aldo-keto reductase family 1 member C1 regulates the osteogenic differentiation of human ASCs by targeting the progesterone receptor.

Xuenan LiuXiaomin LianXuejiao LiuYangge DuYuan ZhuMenglong HuPing ZhangYunsong LiuYongsheng Zhou

Published in: Stem cell research & therapy (2021)

Collectively, our study suggested that AKR1C1 could serve as a regulator of osteogenic differentiation via targeting PGR and be used as a new molecular target for ASCs modification in bone tissue engineering.

Keyphrases

tissue engineering
endothelial cells
mesenchymal stem cells
bone marrow
bone mineral density
transcription factor
induced pluripotent stem cells
cancer therapy
estrogen receptor
single molecule
soft tissue
drug delivery
postmenopausal women