Jason M. Peters works in the fields of antibiotic resistance and biofuel production. In this mSphere of Influence article, he reflects on how the paper "A global genetic interaction network maps a wiring diagram of cellular function" by Costanzo et al. (Science 353:aaf1420, 2016, https://doi.org/10.1126/science.aaf1420) has impacted his work by highlighting the power of gene networks to uncover new biology.