Transforming growth factors β and their signaling pathway in renal cell carcinoma and peritumoral space-transcriptome analysis.
Dariusz KajdaniukDorota HudyJoanna Katarzyna StrzelczykKrystyna MłynarekSzymon SłomianAndrzej PotykaEwa SzymonikJanusz StrzelczykWanda FoltynBeata Kos-KudlaBogdan MarekPublished in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2023)
On the one hand, the underexpression of the TGFβ signaling pathway genes within the malignant tumor may result in the loss of the antiproliferative and pro-apoptotic activity of this cytokine. On the other hand, the overexpression of the TGFβ/Smads pathway genes in the TME than in tumor or NK tissues most probably results in an immunosuppressive effect in the space surrounding the tumor and may have an antiproliferative and pro-apoptotic effect on non-neoplastic cells present in the TME. The functional and morphological consistency of this area may determine the aggressiveness of the tumor and the time in which the neoplastic process will spread.