14-3-3ζ targeting induced senescence in Hep-2 laryngeal cancer cell through deneddylation of Cullin1 in the Skp1-Cullin-F-box protein complex.

Sung Bin SeoJi-Ye BaekJi-Hee LimXuyan JinMun-Yong LeeJeong Hwa Lee

Published in: Cell proliferation (2019)

14-3-3ζ negatively regulates senescence in Hep-2 cells, suggesting that 14-3-3ζ targeting may serve to suppress the expansion of laryngeal cancer via induction of senescence through the Cul-1/SCFSkp2 /p27 axis.

Keyphrases

endothelial cells
dna damage
high glucose
stress induced
induced apoptosis
cancer therapy
papillary thyroid
cell cycle arrest
binding protein
transcription factor
diabetic rats
oxidative stress
signaling pathway
squamous cell
protein protein
young adults
pi k akt