Extent, pattern, and prognostic value of MGMT promotor methylation: does it differ between glioblastoma and IDH-wildtype/TERT-mutated astrocytoma?

Nico TeskePhilipp KarschniaJonathan WellerSebastian SillerMario M DorostkarJochen HermsLouisa von BaumgartenJoerg Christian TonnNiklas Thon

Published in: Journal of neuro-oncology (2021)

Extent and pattern of methylated CpG sites are similar in glioblastoma and IDHwt astrocytoma with pTERTmut. In both tumor entities, higher numbers of methylated CpG sites appear associated with more favourable outcome. Evaluation in larger prospective cohorts is warranted.

Keyphrases

dna methylation
genome wide
wild type
low grade
gene expression