A DNA copy number alteration classifier as a prognostic tool for prostate cancer patients.
Walead EbrahimizadehKarl-Philippe GuérardShaghayegh RouzbehEleonora ScarlataFadi BrimoPalak G PatelTamara JamaspishviliLucie HamelArmen G AprikianAnna Y LeeDavid M BermanJohn M S BartlettSimone ChevalierJacques LapointePublished in: British journal of cancer (2023)
The 6-gene CNA classifier generated by a single MLPA assay compatible with the small quantities of DNA extracted from formalin-fixed paraffin-embedded (FFPE) tissue specimens has the potential to improve the clinical management of patients with low or intermediate risk disease.
Keyphrases
- copy number
- prostate cancer
- mitochondrial dna
- end stage renal disease
- genome wide
- circulating tumor
- chronic kidney disease
- ejection fraction
- cell free
- peritoneal dialysis
- newly diagnosed
- single molecule
- radical prostatectomy
- high throughput
- dna methylation
- gene expression
- human health
- transcription factor
- risk assessment
- single cell
- ultrasound guided