Treatment effects in randomised trials using routinely collected data for outcome assessment versus traditional trials: meta-research study.

Kimberly A Mc CordHannah EwaldArnav AgarwalDominik GlinzSoheila AghlmandiJohn P A IoannidisLars G Hemkens

Published in: BMJ (Clinical research ed.) (2021)

Randomised clinical trials using routinely collected data for outcome ascertainment show smaller treatment benefits than traditional trials not using routinely collected data. These differences could have implications for healthcare decision making and the application of real world evidence.

Keyphrases

clinical trial
healthcare
electronic health record
open label
big data
decision making
machine learning
placebo controlled
phase ii
data analysis
replacement therapy
health insurance
artificial intelligence