Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids.
Vanessa Derenji de MelloRatika SehgalVille MännistöAnton KlåvusEmma NilssonAlexander PerfilyevDorota KaminskaZong MiaoPäivi PajukantaCharlotte LingKati HanhinevaJussi PihlajamäkiPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
We found that serum levels of the NASH-related AAAs and BCAAs demonstrate divergent associations with serum lipids. The specific correlation of tryptophan with LDL-c may result from the molecular events affecting LDLR mRNA expression and NASH-associated methylation of genes in the liver.