SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation.
Yu ZhangQianbo ChenDashuang ChenWenqi ZhaoHaowei WangMei YangZhenghua XiangHong-Bin YuanPublished in: CNS neuroscience & therapeutics (2021)
SerpinA3N is expressed in astrocytes and penumbra neurons after stroke in mice. It reduces brain damage possibly via interacting with clusterin and inhibiting neuronal apoptosis and neuroinflammation.
Keyphrases
- cerebral ischemia
- oxidative stress
- endoplasmic reticulum stress
- cell cycle arrest
- lipopolysaccharide induced
- traumatic brain injury
- lps induced
- cell death
- cognitive impairment
- subarachnoid hemorrhage
- spinal cord
- signaling pathway
- brain injury
- blood brain barrier
- type diabetes
- high fat diet induced
- resting state
- pi k akt
- protein kinase
- skeletal muscle