Genetic Basis of Early Onset Atrial Fibrillation in Patients without Risk Factors.
Irina RudakaBaiba VilneJekaterina IsakovaOskars KalejsLinda GailiteDmitrijs RotsPublished in: Journal of cardiovascular development and disease (2023)
We observed a high prevalence of pathogenic/likely pathogenic variants in cardiomyopathy-associated genes in patients with risk factor-free early-onset AF. Moreover, our follow-up imaging data indicate that these types of patients are at risk of developing ventricular dilation. Furthermore, we identified two TTNtvs founder variants in our Latvian study population.
Keyphrases
- early onset
- risk factors
- end stage renal disease
- atrial fibrillation
- late onset
- newly diagnosed
- ejection fraction
- heart failure
- prognostic factors
- chronic kidney disease
- peritoneal dialysis
- gene expression
- high resolution
- coronary artery disease
- acute coronary syndrome
- percutaneous coronary intervention
- catheter ablation
- mass spectrometry
- venous thromboembolism
- transcription factor
- bioinformatics analysis