Chimeric antigen receptor T cells targeting PD-L1 suppress tumor growth.
Le QinRuocong ZhaoDongmei ChenXinru WeiQiting WuYouguo LongZhiwu JiangYangqiu LiHaipeng WuXuchao ZhangYilong WuShuzhong CuiWei WeiHuihui YaoZixia LiuSu CaoYao YaoZhenfeng ZhangJiang LvPublished in: Biomarker research (2020)
In conclusion, we demonstrate CAR-T cells targeting PD-L1 were effective for suppressing the growth of multiple types of solid tumors in PDX models though their safety needs to be carefully examined.