DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development.

Szu-Yuan LiJiwhan ParkYuting GuanKiwung ChungRojesh ShresthaMatthew B PalmerKatalin Suszták

Published in: Journal of the American Society of Nephrology : JASN (2019)

Genome-wide cytosine methylation and gene expression profiling showed that by silencing embryonic, nonrenal lineage genes and transposable elements, DNMT1-mediated cytosine methylation is essential for kidney development.

Keyphrases

genome wide
dna methylation
copy number
gene expression
genome wide identification
single cell