The H2TH-like motif of the Escherichia coli multifunctional protein KsgA is required for DNA binding involved in DNA repair and the suppression of mutation frequencies.
Yuichiro HayashiMasafumi FunakoshiKaname HirosawaQiu-Mei Zhang-AkiyamaPublished in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2023)
The present results confirmed that one enzyme exhibited two activities and revealed that the C-terminal (214-273) amino acids of KsgA were highly similar to the H2TH structural domain, exhibited DNA-binding activity, and inhibited spontaneous mutations. This site is not essential for dimethyltransferase activity.