Rh(III)-Catalyzed Carboamination of Propargyl Cycloalkanols with Arylamines via Csp2-H/Csp3-Csp3 Activation.

Xinwei HuXun ChenYong ZhuYuanfu Deng Huaqiang Zeng Huan-Feng Jiang Wei Zeng

Published in: Organic letters (2017)

A Rh(III)-catalyzed carboamination of alkynyl cycloalkanols with arylamines has been developed. This transformation involves a novel Csp2-H/Csp3-Csp3 activation relay and provides an efficient approach to versatile 1,2,3-trisubstituted indoles with a broad range of functional group tolerance.

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