Dissecting the role of cancer-associated fibroblast-derived biglycan as a potential therapeutic target in immunotherapy resistance: A tumor bulk and single-cell transcriptomic study.

Shaoquan ZhengJie-Ying LiangYuhui TangJindong XieYutian ZouAnli YangNan ShaoXiaying KuangFei JiXuefeng LiuWenwen TianWeikai XiaoYing Lin

Published in: Clinical and translational medicine (2023)

We highlighted the importance of CAFs in the tumor microenvironment and revealed that the BGN, which is mainly derived from CAFs, may be applicable in clinical practice and serve as a therapeutic target in immunotherapy resistance.

Keyphrases

single cell
rna seq
clinical practice
risk assessment
human health
wound healing