Epigenetic Modification Factors and microRNAs Network Associated with Differentiation of Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Cardiomyocytes: A Review.
Afshin ZareAria SalehpourArezoo KhoradmehrShabnam BakhshalizadehVahid NajafzadehSahar Almasi-TurkMahdi MahdipourReza ShiraziAmin TamadonPublished in: Life (Basel, Switzerland) (2023)
More research is being conducted on myocardial cell treatments utilizing stem cell lines that can develop into cardiomyocytes. All of the forms of cardiac illnesses have shown to be quite amenable to treatments using embryonic (ESCs) and induced pluripotent stem cells (iPSCs). In the present study, we reviewed the differentiation of these cell types into cardiomyocytes from an epigenetic standpoint. We also provided a miRNA network that is devoted to the epigenetic commitment of stem cells toward cardiomyocyte cells and related diseases, such as congenital heart defects, comprehensively. Histone acetylation, methylation, DNA alterations, N6-methyladenosine (m 6 a) RNA methylation, and cardiac mitochondrial mutations are explored as potential tools for precise stem cell differentiation.
Keyphrases
- induced pluripotent stem cells
- dna methylation
- stem cells
- cell therapy
- left ventricular
- gene expression
- embryonic stem cells
- genome wide
- single cell
- high glucose
- induced apoptosis
- cell cycle arrest
- angiotensin ii
- heart failure
- risk assessment
- cell free
- circulating tumor
- signaling pathway
- cell death
- cell proliferation
- atrial fibrillation
- nucleic acid