Eosinophils protect against acetaminophen-induced liver injury through cyclooxygenase-mediated IL-4/IL-13 production.

Long Xu Yang YangJiali JiangYankai WenJong-Min JeongChristoph EmontzpohlConstance Lynn AtkinsKangho KimElizabeth A JacobsenHua WangCynthia Ju

Published in: Hepatology (Baltimore, Md.) (2022)

The current study revealed that eosinophil-derived IL-4/IL-13 accounted for the hepatoprotective effect of eosinophils during AILI. The data demonstrated that the p38 MAPK/COX/NF-κB signaling cascade played a critical role in inducing IL-4/IL-13 production by eosinophils in response to IL-33.

Keyphrases

signaling pathway
machine learning
cell proliferation
big data
inflammatory response
toll like receptor