Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder.

Giuseppe GalvaniNicola MottoleseLaura GennaccaroManuela LoiGiorgio MediciMarianna TassinariClaudia FuchsElisabetta CianiStefania Trazzi

Published in: Journal of neuroinflammation (2021)

Our results suggest that neuroinflammatory processes contribute to the pathogenesis of CDD and imply the potential usefulness of luteolin as a treatment option in CDD patients.

Keyphrases

mouse model
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
inflammatory response
patient reported outcomes
neuropathic pain
spinal cord
blood brain barrier
replacement therapy
patient reported
climate change
human health