Targeting Tumorigenicity of Breast Cancer Stem Cells Using SAHA/Wnt-b Catenin Antagonist Loaded Onto Protein Corona of Gold Nanoparticles.

Azam ShamsianMohammad Reza SepandMarziye Javaheri KachousangiTahereh DaraSeyed Nasser OstadFatemeh AtyabiMohammad Hossein Ghahremani

Published in: International journal of nanomedicine (2020)

Our study reveals the PC-coated GNPs as a biocompatible career for both hydrophilic (PKF) and hydrophobic (SAHA) agents which can decrease breast cancer stem cell populations along with reduced stemness state regression.

Keyphrases

cancer stem cells
gold nanoparticles
cell proliferation
cancer therapy
histone deacetylase
ionic liquid
stem cells
drug delivery
protein protein
binding protein
wound healing
small molecule
reduced graphene oxide
solid phase extraction
high resolution
signaling pathway
genetic diversity
simultaneous determination