Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury.

Chang-Hong DuYi-Ding WuKe YangWei-Nian LiaoLi RanChao-Nan LiuShu-Zhen ZhangKuan YuJun ChenYong QuanMo ChenMing-Qiang ShenHong TangShi-Lei ChenSong WangJing-Hong ZhaoTian-Min ChengJun-Ping Wang

Published in: Military Medical Research (2023)

Our study identifies that megakaryocytic mitochondria-cGAS/STING-IFN-β-GBP2 axis serves as a fundamental checkpoint that instructs the size and function of platelets upon radiation injury and can be harnessed to treat platelet pathologies.

Keyphrases

cell death
dna damage
oxidative stress
endoplasmic reticulum stress
genome wide
immune response
cell cycle
radiation induced
dendritic cells
reactive oxygen species
red blood cell
dna methylation