Cytokine release syndrome - a unique entity of Augmentin hypersensitivity reaction.
Lynette Liling TanMay Ping LeeSi Hui GohHwee Hoon LimAnne Goh Eng NeoKok Wee ChongPublished in: Asia Pacific allergy (2022)
Cytokine release syndrome (CRS) is a type of hypersensitivity reaction which has been previously described with chemotherapy and monoclonal antibodies, but not with antibiotics. We present 2 pediatric cases of Amoxicillin/Clavulanic acid (Augmentin) anaphylaxis resembling CRS. Both our patients presented during the index reaction with symptoms suggestive of an acute systemic inflammatory response mimicking sepsis. Their symptomology was reproducible at drug provocation test as anaphylaxis, but with suboptimal response to intramuscular adrenaline. Their infective workups were unremarkable and illnesses followed a self-limiting course. All these point towards a severe hypersensitivity reaction resembling CRS.
Keyphrases
- drug induced
- inflammatory response
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- case report
- acute kidney injury
- intensive care unit
- liver failure
- emergency department
- lipopolysaccharide induced
- patient reported outcomes
- adverse drug
- toll like receptor
- immune response
- lps induced
- young adults
- hepatitis b virus