Login / Signup

Towards a Future of Personalized Vaccinology: Study on Individual Variables Influencing the Antibody Response to the COVID-19 Vaccine.

Giuseppa VisalliAntonio LaganàDaniela Lo GiudiceSebastiano CalimeriDaniela CaccamoAlessandra TrainitoAngela Di PietroAlessio Facciolà
Published in: Vaccines (2023)
The COVID-19 pandemic has hugely impacted many different aspects of human health, and vaccination is one of the most effective weapons to manage it. However, many different factors, such as age, gender, comorbidities and lifestyles, play a role in the response to infections and vaccines. We carried out this study to evaluate the potential role played by some individual factors in the production of anti-COVID-19 antibodies in the light of personalized and future vaccinology. We conducted an observational study consisting of a retrospective phase, exploiting previous data about anti-COVID-19 antibody responses, with a prospective phase to investigate individual variables through the use of a questionnaire. The antibody response after the COVID-19 vaccination was inversely related to old age, increased BMI and the number of smoking years, while a positive correlation was found with moderate alcohol consumption and especially with circulating levels of vitamin D, as clearly shown by the multivariate regression analysis. Our study showed that a number of variables are involved in the COVID-19 vaccine antibody response. These findings are very important and can be considered in the light of a future and personalized vaccinology.
Keyphrases
  • coronavirus disease
  • sars cov
  • human health
  • risk assessment
  • alcohol consumption
  • body mass index
  • machine learning
  • smoking cessation
  • physical activity
  • electronic health record
  • drug induced