Effects of GLP-1 infusion upon whole-body glucose uptake and skeletal muscle perfusion during fed-state in older men.

Haitham AbdullaBethan PhillipsDaniel WilkinsonAmanda GatesMarie LimbTereza JandovaJoseph BassJohnathan LewisJohn WilliamsKenneth SmithIskandar IdrisPhilip J Atherton

Published in: The Journal of clinical endocrinology and metabolism (2022)

The beneficial effects of GLP-1 upon whole-body glycaemic control are evident with insulin clamped at fed-state levels. GLP-1 further enhances the effects of insulin on whole-body glucose uptake in older men, underlining its role as a therapeutic target. The effects of GLP-1 in enhancing microvascular flow likely also impacts other glucose-regulatory organs, reflected by greater whole-body glucose uptake.

Keyphrases

type diabetes
blood glucose
middle aged
skeletal muscle
glycemic control
physical activity
low dose
community dwelling
blood pressure
magnetic resonance imaging
transcription factor
metabolic syndrome
magnetic resonance