In situ vaccination with cowpea mosaic virus elicits systemic antitumor immunity and potentiates immune checkpoint blockade.

Chenkai MaoVeronique BeissGregory W HoJennifer FieldsNicole F SteinmetzSteven N Fiering

Published in: Journal for immunotherapy of cancer (2022)

These findings provide new insights into in situ TLR activation and cDC1 recruitment as effective strategies to overcome resistance to immunotherapy in treated and untreated tumors.

Keyphrases

toll like receptor
inflammatory response
immune response
drug induced