A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies.
André AltmannMina RytenMartina Di NunzioTeresa RavizzaDaniele TolomeoRegina H ReynoldsAlyma SomaniMarco BacigaluppiValentina IoriEdoardo MicottiRossella Di SapiaMilica CerovicEleonora PalmaGabriele RuffoloJuan A BotíaJulie AbsilSaud AlhusainiMarina K M AlvimPia AuvinenNuria BargalloEmanuele BartoliniBenjamin BenderFelipe P G BergoTauana BernardesAndrea BernasconiNeda BernasconiBoris C BernhardtKaren BlackmonBarbara BragaMaria Eugenia CaligiuriAnna CalvoChad CarlsonSarah J A CarrGianpiero L CavalleriFernando CendesJian ChenShuai ChenAndrea CherubiniLuis ConchaPhilippe DavidNorman DelantyChantal DepondtOrrin DevinskyColin P DohertyMartin DominNiels K FockeSonya FoleyWendy FrancaAntonio GambardellaRenzo GuerriniKhalid HamandiDerrek P HibarDmitry IsaevGraeme D JacksonNeda JahanshadReetta KälviäinenSimon S KellerPeter KochunovRaviteja KotikalapudiMagdalena A KowalczykRuben KuznieckyPatrick KwanAngelo LabateSoenke LangnerMatteo LengeMin LiuPascal MartinMario MascalchiStefano MelettiMarcia E Morita-ShermanTerence J O'BrienJose C ParienteMark P RichardsonRaul Rodriguez-CrucesChristian RummelTaavi SaavalainenMira K SemmelrochMariasavina SeverinoPasquale StrianoThomas ThesenRhys H ThomasManuela TondelliDomenico TortoraAnna Elisabetta VaudanoLucy VivashFelix von PodewilsJan WagnerBernd WeberRoland WiestClarissa L YasudaGuohao ZhangJunsong Zhangnull nullCostin LeuAndreja Avberseknull nullMaria ThomChristopher D WhelanPaul ThompsonCarrie R McDonaldAnnamaria VezzaniSanjay M SisodiyaPublished in: Neuropathology and applied neurobiology (2021)
These convergent data strongly implicate activated microglia in cortical thinning, representing a new dimension for concern and disease modification in the epilepsies, potentially distinct from seizure control.