Stroke, the third leading cause of mortality, is usually associated with severe disabilities, high recurrence rate and other poor outcomes. Currently, there are no long-term effective treatments for stroke. Cell and cytokine therapies have been explored previously. However, the therapeutic outcomes are often limited by poor survival of transplanted cells, uncontrolled cell differentiation, ineffective engraftment with host tissues and non-sustained delivery of growth factors. A tissue-engineering approach provides an alternative for treating ischemic stroke. The key design considerations for the tissue engineering approach include: choice of scaffold materials, choice of cells and cytokines and delivery methods. Here, we review current cell and biomaterial based therapies available for ischemic stroke, with a special focus on tissue-engineering strategies for regeneration of stroke-affected neuronal tissue.
Keyphrases
- tissue engineering
- atrial fibrillation
- induced apoptosis
- cell cycle arrest
- single cell
- cell therapy
- stem cells
- cerebral ischemia
- gene expression
- risk factors
- early onset
- oxidative stress
- cell death
- signaling pathway
- cardiovascular disease
- adipose tissue
- metabolic syndrome
- coronary artery disease
- subarachnoid hemorrhage
- cell proliferation
- bone marrow