Effects of dapagliflozin on volume status and systemic haemodynamics in patients with chronic kidney disease without diabetes: Results from DAPASALT and DIAMOND.
Taha SenRosalie A ScholtesPeter J GreasleyDavid Z I CherneyClaire C J DekkersMarc G VervloetAlexander H J DanserSean J BarbourCecilia KarlssonAnn HammarstedtQiang LiGozewijn D LavermanPetter BjornstadDaniel H van RaalteHiddo J Lambers HeerspinkPublished in: Diabetes, obesity & metabolism (2022)
During a standardized sodium diet, dapagliflozin decreased BP but did not increase 24-hour sodium and volume excretion. The lack of increased natriuresis and diuresis may be attributed to activation of intra-renal compensatory mechanisms to prevent excessive water loss.