Intravenous Acetaminophen Overdose in an Infant With Toxicokinetic Data.

Joshua D Trebach Sarah G Mahonski Kristina MelchertMary Ann HowlandWilliam K Chiang

Published in: Journal of pharmacy practice (2021)

This case report adds to the existing literature regarding toxicokinetics of IV APAP in infants. Our patient had a calculated ke of 0.263 h-1, correlating with a half-life of 2.63 hours. Based on current available data, the half-life of IV APAP in infants varies (2.6 to 4.9 hours). The reason for this variation is unknown and further research is needed in this area.

Keyphrases

case report
electronic health record
big data
systematic review
low dose
liver injury
artificial intelligence