A Fast and Robust Strategy to Remove Variant-Level Artifacts in Alzheimer Disease Sequencing Project Data.

Michael E Belloy Yann Le Guen Sarah J Eger Valerio NapolioniMichael D GreiciusZihuai He

Published in: Neurology. Genetics (2022)

We derived a fast and robust approach to filter variants that represent sequencing center-related or platform-related artifacts underlying spurious associations with AD risk in ADSP WES and WGS data. This approach will be important to support future robust genetic association studies on ADSP data, as well as other studies with similar designs.

Keyphrases

electronic health record
big data
single cell
copy number
magnetic resonance imaging
quality improvement
gene expression
computed tomography
genome wide
dna methylation
cone beam