Microbiological Species and Antibiotic Resistance in Diabetic and Nondiabetic Lower Extremity Wounds: A Comparative Cross-Sectional Study.
Vanessa Prado SantosMaria G M de Andrade BarberinoCarlos A S AlvesPublished in: The international journal of lower extremity wounds (2021)
Severe lower extremity wounds have an increased risk of complications and limb loss. The aim of this study was to evaluate and compare the microbiological profile and antibiotic resistance of wounds in diabetic and nondiabetic patients. A cross-sectional comparative study was carried out at a public hospital including 111 patients with moderate to severe wound infections. Tissue samples were collected during a surgical procedure. One hundred and four patients (94%) had positive cultures and 88 (79%) had a Gram-negative microorganism. Among the 185 cultured microorganisms, 133 (72%) were Gram-negative species. Pseudomonas aeruginosa (23 cases) was the most isolated Gram-negative species, and Enterococcus faecalis (26 cases) was the most prevalent Gram-positive species. Among 185 isolated species, 45 (24%) were extended-spectrum beta-lactamase producers, 23 (12%) were carbapenem-resistant, and 5 (3%) were methicillin-resistant Staphylococcus aureus. Findings revealed that there was no significant difference in the microbiological profile and antibiotic resistance among patients with lower extremity wounds whether they were diabetic or nondiabetic.
Keyphrases
- gram negative
- multidrug resistant
- end stage renal disease
- wound healing
- methicillin resistant staphylococcus aureus
- drug resistant
- pseudomonas aeruginosa
- acinetobacter baumannii
- ejection fraction
- chronic kidney disease
- newly diagnosed
- healthcare
- escherichia coli
- peritoneal dialysis
- prognostic factors
- staphylococcus aureus
- genetic diversity
- minimally invasive
- mental health
- endothelial cells
- patient reported outcomes
- klebsiella pneumoniae
- high intensity