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Reconstituted cryopreserved platelets synthesize proteins during short-term storage and packaging a defined subset into microvesicles.

Peter SchubertLacey JohnsonBrankica CulibrkZhongming ChenShereen TanDenese C MarksDana V Devine
Published in: Transfusion (2021)
Cryo-PLTs can synthesize proteins upon reconstitution and storage. Discovery of a subset of these proteins in the PMV suggests a role in vesicle encapsulation, possibly in a selective manner. This observation provides novel insights into the capacity for protein synthesis in cryo-PLTs and the potential regulation of protein packaging into PMV.
Keyphrases
  • high resolution
  • small molecule
  • electron microscopy
  • protein protein
  • bone marrow
  • binding protein
  • cord blood
  • red blood cell