Soluble Neuropilin-1 Is Elevated in Sepsis and Correlates with Organ Dysfunction and Long-Term Mortality in Critical Illness.
Philipp HohlsteinEileen SchumacherSamira Abu JhaishaJule K AdamsMaike R PollmannsCarolin V SchneiderKarim HameschKatarina HorvathovaTheresa H WirtzFrank TackeChristian TrautweinRalf WeiskirchenAlexander KochPublished in: International journal of molecular sciences (2024)
Critical illness and sepsis may cause organ failure and are recognized as mortality drivers in hospitalized patients. Neuropilin-1 (NRP-1) is a multifaceted transmembrane protein involved in the primary immune response and is expressed in immune cells such as T and dendritic cells. The soluble form of NRP-1 (sNRP-1) acts as an antagonist to NRP-1 by scavenging its ligands. The aim of this study was to determine the value of sNRP-1 as a biomarker in critical illness and sepsis. We enrolled 180 critically ill patients admitted to a medical intensive care unit and measured serum sNRP-1 concentrations at admission, comparing them to 48 healthy individuals. Critically ill and septic patients showed higher levels of sNRP-1 compared to healthy controls (median of 2.47 vs. 1.70 nmol/L, p < 0.001). Moreover, sNRP-1 was also elevated in patients with sepsis compared to other critical illness (2.60 vs. 2.13 nmol/L, p = 0.01), irrespective of disease severity or organ failure. In critically ill patients, sNRP-1 is positively correlated with markers of kidney and hepatic dysfunction. Most notably, critically ill patients not surviving in the long term (one year after admission) showed higher concentrations of sNRP-1 at the time of ICU admission ( p = 0.036), with this association being dependent on the presence of organ failure. Critically ill and septic patients exhibit higher serum concentrations of circulating sNRP-1, which correlates to organ failure, particularly hepatic and kidney dysfunction.
Keyphrases
- intensive care unit
- acute kidney injury
- end stage renal disease
- dendritic cells
- immune response
- emergency department
- ejection fraction
- newly diagnosed
- chronic kidney disease
- septic shock
- peritoneal dialysis
- oxidative stress
- prognostic factors
- type diabetes
- mechanical ventilation
- risk factors
- patient reported outcomes
- inflammatory response
- patient reported