Cannabinoids versus placebo for pain: A systematic review with meta-analysis and Trial Sequential Analysis.
Jehad BarakjiSteven Kwasi KorangJoshua Buron FeinbergMathias MaagaardOle MathiesenChristian GluudJanus Christian JakobsenPublished in: PloS one (2023)
Cannabinoids reduced chronic pain and improved quality of sleep, but the effect sizes are of questionable importance. Cannabinoids had no effects on acute pain or cancer pain and increased the risks of non-serious adverse events. The harmful effects of cannabinoids for pain seem to outweigh the potential benefits.