Epidermal growth factor receptor targeted methotrexate and small interfering RNA co-delivery.

Benjamin SteinbornInes TruebenbachStephan MorysUlrich Lächelt Ernst WagnerWei Zhang

Published in: The journal of gene medicine (2018)

A new strategy for co-delivering negatively charged MTX and cytotoxic siRNA has been developed by utilizing sequence defined cationic lipo-oligomers. Mediated by the combined effect of antifolate MTX, antimitotic EG5 siRNA and EGFR targeting by GE11, superior tumor cell killing was obtained with GE11 gE2 -MTX or gE5 -MTX EG5 siRNA/454 polyplexes.

Keyphrases

epidermal growth factor receptor
cancer therapy
tyrosine kinase
advanced non small cell lung cancer
drug delivery
small cell lung cancer
cell therapy
hyaluronic acid
high dose
stem cells