Hypolipidemic and anti-inflammatory properties of phenolic rich Butia odorata fruit extract: potential involvement of paraoxonase activity.
Vanessa Plasse RamosPamela Gonçalves da SilvaPathise Souto OliveiraNatália Pontes BonaMayara Sandrielly Pereira SoaresJuliane De Souza CardosoJessica Fernanda HoffmannFábio Clasen ChavesAugusto SchneiderRoselia Maria SpanevelloClaiton Leoneti LencinaFrancieli Moro StefanelloRejane Giacomelli TavaresPublished in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (2020)
Aim: This study investigated the effects of polar Butia odorata fruit extract on metabolic, inflammatory, and oxidative stress parameters in rats submitted to a hyperlipidaemia condition induced by tyloxapol.Methods: Animals were divided into 3 groups: saline, saline plus tyloxapol, and B. odorata extract plus tyloxapol. Animals were treated for 15 days with a saline solution or B. odorata fruit extract and after hyperlipidaemia was induced by tyloxapol.Results: Treatment with B. odorata extract reduced serum triglyceride, total cholesterol, C-reactive protein, and adenosine deaminase and butyrylcholinesterase activities when compared to the tyloxapol group. HDL-cholesterol and paraoxonase 1 activity were higher in B. odorata extract treated animals when compared to tyloxapol-treated animals. No differences were observed in hepatic oxidative stress parameters. Phenolic compounds present in B. odorata fruit extract were identified and quantified by LC-MS/MS.Conclusion: These findings indicated that phenolic rich B. odorata extract has hypolipidemic and anti-inflammatory effects in hyperlipidemic rats.