Estrogen receptor and immune checkpoint inhibitors: new partners in lung cancer?

Karmele Valencia Luis M Montuenga Alfonso Calvo

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

The influence of sex on immunotherapy response in NSCLC patients had been studied with no clear conclusions. An article in this issue reports that a key determinant of response is not sex but the existence of a 17-β-estradiol/ERα/PDL1 signaling loop in NSCLC. This intriguing result opens new therapeutic options.

Keyphrases

estrogen receptor
small cell lung cancer
end stage renal disease
ejection fraction
chronic kidney disease
advanced non small cell lung cancer
prognostic factors
emergency department
brain metastases
hiv testing
men who have sex with men
breast cancer cells