Prevention of allergy by virus-like nanoparticles (VNP) delivering shielded versions of major allergens in a humanized murine allergy model.

Bernhard KratzerCordula KöhlerSandra HoferUrsula SmoleDoris TrapinJagoba IturriDietmar PumPhilip KienzlAdelheid Elbe-BuergerPia GattingerIrene MittermannBirgit LinhartGabriele Gadermaier Beatrice Jahn-SchmidAlina NeunkirchnerRudolph Valenta Winfried F Pickl

Published in: Allergy (2018)

Virus-like nanoparticles represent a novel and versatile platform for the in vivo delivery of allergens to selectively target T cells and prevent allergies without inducing allergic reactions or allergic sensitization.

Keyphrases

atopic dermatitis
allergic rhinitis

infectious diseases
high throughput

walled carbon nanotubes
disease virus

monoclonal antibody