Male-specific late effects in adult hematopoietic cell transplantation recipients: a systematic review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation.
Rachel PhelanAnnie ImRebecca L HunterYoshihiro InamotoMaria Teresa Lupo-StanghelliniAlicia RovoSherif M BadawyLinda J BurnsHesham EissaHemant S MurthyPinki PrasadAkshay SharmaElizabeth M SuelzerVaibhav AgrawalMahmoud AljurfKaren BakerGrzegorz Władysław BasakDavid BuchbinderZachariah DeFilippLana Desnica GrkovicAjoy DiasHermann EinseleMichael L EisenbergNarendranath EpperlaNosha FarhadfarArthur FlatauRobert Peter GaleHildegard GreinixBetty K HamiltonShahrukh HashmiPeiman HemattiKareem JamaniDipnarine MaharajJohn MurraySeema G NaikSunita NathanSteven PavleticZinaida PerićDrazen PulanicRichard J RossAndrea SaloniaIsabel Sanchez-OrtegaBipin N SavaniTal SchechterAmi J ShahStephanie M SmithJohn A SnowdenAmir SteinbergDouglas TremblaySarah C VijLauren WalkerDaniel WolffJean A YaredHélène M SchoemansAndré TichelliPublished in: Bone marrow transplantation (2022)
Male-specific late effects after hematopoietic cell transplantation (HCT) include genital chronic graft-versus-host disease (GvHD), hypogonadism, sexual dysfunction, infertility, and subsequent malignancies. They may be closely intertwined and cause prolonged morbidity and decreased quality of life after HCT. We provide a systematic review of male-specific late effects in a collaboration between transplant physicians, endocrinologists, urologists, dermatologists, and sexual health professionals through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research, and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. The systematic review summarizes incidence, risk factors, screening, prevention and treatment of these complications and provides consensus evidence-based recommendations for clinical practice and future research.