Regioselective synthesis of gentisyl alcohol-type marine natural products.

Hong-Shuang WangHui-Jing LiLong-Fei WangZhi-Lun ShenYan-Chao Wu

Published in: Natural product research (2018)

Gentisyl alcohol-type natural products, possessing various important biological properties, have been synthesized from 4-methoxyphenol by using a selective phenol monohydroxymethylation/monochlorination, a CAN oxidation and a sodium dithionite reduction as the key steps. The natural product synthesis is efficient, atom- and step-economical, and requires no protecting groups.

Keyphrases

alcohol consumption
molecular dynamics
electron transfer