Increased frequency of interleukin-4 and reduced frequency of interferon-γ and IL-17-producing CD4+ and CD8+ cells in scleromyxedema.
F KalliM CioniA ParodiT AltosoleF FerreraG BarraR De PalmaD FenoglioG FilaciFranco RongiolettiPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2020)
Our data indicate that a chronic Th2-skewed T-cell response against an unknown target antigen leading to abnormally high IL4 secretion, a pro-fibrotic cytokine, is a main immunological hallmark of scleromyxedema patients. These results, never reported before, may have a translational therapeutic value due to the availability of anti-IL4 agents such as dupilumab.
Keyphrases
- end stage renal disease
- induced apoptosis
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- systemic sclerosis
- cell cycle arrest
- big data
- machine learning
- atopic dermatitis
- electronic health record
- nk cells
- cell death
- patient reported outcomes
- oxidative stress
- signaling pathway
- immune response
- artificial intelligence