A secondary CD34+ acute lymphoblastic leukemia unmasked and mobilized by G-CSF in an autologous stem cell donor with testicular cancer.
Laura CoolingJustin KelleyEdison SextonSarah AnandSandra HoffmannPublished in: Transfusion (2023)
We report a case of t-ALL that mimicked CD34+ HPC and was mobilized by high-dose G-CSF. Up to 70% of secondary leukemias bear 11q23/KMT2A rearrangements, which occur at the multipotent stem cell stage and can result in myeloid and lymphoid leukemias. Donors who have received past chemotherapy, especially with topoisomerase II inhibitors, are at increased risk for 11q23/KMT2A leukemias.
Keyphrases
- stem cells
- acute lymphoblastic leukemia
- high dose
- peripheral blood
- bone marrow
- cell therapy
- papillary thyroid
- low dose
- acute myeloid leukemia
- nk cells
- squamous cell
- allogeneic hematopoietic stem cell transplantation
- dendritic cells
- cerebrospinal fluid
- locally advanced
- immune response
- kidney transplantation
- squamous cell carcinoma
- mesenchymal stem cells
- platelet rich plasma
- radiation therapy
- germ cell