A spiropyran-decorated nanocoating for dynamically regulating bacteria/cell adhesion and detachment.
Jie LiZhuang MaAnran LiSiyuan HuangYufei ZhangYun XueXianhui SongYe ZhangShihao HongMo WangZhongming WuXinge ZhangPublished in: Journal of materials chemistry. B (2023)
Microorganism adhesion and the resulting contamination of the biomaterial is one of the major causes of biomedical device failure. Stimuli-responsive materials based on dynamically regulating interactions with reversible characteristics of on-off states have attracted increasing attention. Here, a facile self-assembled biomaterial nanocoating constructed using acidity- and photoregulated spiropyran-modified nanoparticles was developed for reversibly regulating bacteria or mammalian cell adhesion-and-detachment. The coating was formed by coating a solution of spiropyran-conjugated nanoparticles around the surface of a silica gel followed by curing and drying at 60 °C for 30 min. Importantly, efficient adhesion-and-detachment of bacteria or cells could be controlled even after 8 cycles owing to the excellent acidity- and light-switched ability. Collectively, this well-defined self-assembled nanocoating as a dynamical and reversible agent provides promising insight for the development of biomedical devices, especially for biomaterial medical coatings.
Keyphrases
- cell adhesion
- induced apoptosis
- reduced graphene oxide
- highly efficient
- quantum dots
- tissue engineering
- risk assessment
- working memory
- wastewater treatment
- photodynamic therapy
- drinking water
- density functional theory
- escherichia coli
- climate change
- health risk
- biofilm formation
- cystic fibrosis
- oxidative stress
- signaling pathway
- endoplasmic reticulum stress
- molecular dynamics
- walled carbon nanotubes
- wound healing
- heavy metals